Lydia Aguilar Bryan, M.D., Ph.D. and Joseph Bryan, Ph.D.
Lydia Aguilar-BryanLydia Aguilar-Bryan, M.D., Ph.D., completed medical school at Universidad Nacional Autónoma de México in Mexico City and earned her Ph.D. in population genetics from the University of Texas Health Science Center in Houston. In graduate school, Aguilar-Bryan focused her research on a population of Mexican-Americans in Star County, Texas with a diabetes prevalence rate of nearly 35%. Most recently, she served as Associate Professor in the Departments of Medicine and Molecular and Cell Biology at Baylor College of Medicine in Houston, Texas. At Baylor College, she also served as an instructor in the Department of Medicine and as a Postdoctoral Fellow in the Division of Endocrinology. Aguilar-Bryan is member of the American Diabetes Association, American Physiological Society, and the Biophysical Society, among others. Aguilar-Bryan is the Associate Editor of Current Molecular Medicine and serves on the Editorial Board for the America Journal of Physiology. Her research interests include understanding the molecular mechanisms by which glucose stimulates insulin secretion. Her laboratory famously cloned the high affinity sulfonylurea receptor (SUR1), the regulatory sub-unit of this channel, and since has been screening for mutations in patients with insulin secretory abnormalities.
Joseph BryanDr. Joseph Bryan received a B.S. in Physics from Rensselaer Polytechnic Institute in Troy, New York. Following completion of his Ph.D. in Anatomy/Cell Biology at University of Pennsylvania, he served as a Postdoctoral Fellow in the Department of Zoology and Cell Biology at the University of California, Berkeley. Dr. Bryan moved in 1980 to Houston, Texas to work as a Professor of Cell Biology in the Department of Cell Biology at Baylor College of Medicine, where he met his future wife, Lydia Aguilar. He stayed at Baylor with Aguilar-Bryan for 20 years before joining the team of principal scientists at PNRI. At Baylor, Bryan and his wife worked for a decade to solve the mysteries of hyperinsulinism. Together, they discovered how the body regulates the secretion of insulin. This major discovery pointed to a protein found in the pancreas cells that controls the process. After isolating that protein, Dr. Joe Bryan and Dr. Lydia Aguilar Bryan were the first to identify the gene that creates insulin, and then showed how mutations in that gene cause familial hyperinsulinism-a disease which is essentially the inverse of diabetes. Bryan serves as a member of the American Diabetes Association, American Physiological Society, Biophysical Society and many more. He is the recipient of the 1996 Michael E. DeBakey, M.D. Excellence in Research Award. He has served on the Editorial Board for seven journals, including the Journal of Biological Chemistry, and the American Journal of Physiology: Endocrinology and Metabolism, on which he currently serves. Bryan has written for nearly 20 prominent journals, including Diabetes, American Journal of Physiology, Kidney International, and many more.
AHANAOA A. C.
Lic. Nut. Miguel Leopoldo Alvarado